la conductance cutanée une aide précieuse dans le suivi des enfants présentant des troubles anxieux-

Stress reactivity predicts symptom improvement in children with anxiety disorders.

Dieleman GC1, Huizink AC2, Tulen JH3, Utens EM4, Tiemeier H5.

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Abstract

BACKGROUND:

We examined the longitudinal associations of autonomic nervous system (ANS) and hypothalamic-pituitary-adrenal (HPA) axis rest and reactivity measures with anxiety and depressive symptoms at one-year follow-up in children with anxiety disorders.

METHODS:

In a clinical sample of 152 children with a primary DSM-IV anxiety disorder, aged 8 to 12 years, anxiety and depressive symptoms were assessed with the Multidimensional Anxiety Scale for Children and the Children's Depression Inventory at pre-treatment baseline and one year later, after treatment with cognitive behavioral therapy. At baseline, children participated in a 70min stress task. Salivary cortisol was measured directly prior to and 20min post stress task. Skin conductance level (SCL), heart rate and high frequency heart rate variability (HRV) were continuously measured during rest and the stress task. To investigate if rest or reactivity measures predicted anxiety and depressivesymptoms at one year follow-up, linear regression analyses were conducted for rest and reactivity measures of SCL, heart rate, HRV and cortisol separately.

RESULTS:

Higher SCL reactivity predicted less decrease of anxiety symptoms at one-year follow-up. Cortisol reactivity showed a weak association with depressive symptoms at one-year follow-up: lower cortisol reactivity predicted less decrease in depressive symptoms.

LIMITATIONS:

Only self-reported anxiety and depressive symptoms were used. However, all predictors were objective biological measures, hence there is no risk of shared method variance bias.

CONCLUSIONS:

These findings suggest that pre-treatment HPA and ANS responsiveness to stress are predictive biomarkers for a lack of symptom improvement in children with a clinical anxiety disorder.

Copyright © 2016 Elsevier B.V. All rights reserved.

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J Affect Disord. 2016 15 mai; 196: 190-9. doi: 10.1016 / j.jad.2016.02.022. Epub 2016 9 février

Stress réactivité prédit une amélioration des symptômes chez les enfants souffrant de troubles anxieux.

Dieleman GC1, Huizink AC2, Tulen JH3, Utens EM4, Tiemeier H5.

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